This research investigates the importance of the spatial distribution of salts in the weathering process of stone decay. The relationship between salt penetration and the intrinsic rock property, permeability, is examined to elucidate the ingress and egress of salt solution in masonry sandstone. The accelerated weathering trial simulates pre-loading a sandstone block with a 10% salt solution (equal parts NaCl and MgSO4) during a wet winter followed by dried out in summer. Permeability data measured from horizontal slices through the block are correlated with salt data from IC analysis. Results indicate relatively high surface permeability values and salt crystallization on exposure to air. The effect of salts blocking pores and reducing permeability is evident in a reduction in permeability in the near surface zone where permeability and (sulphate and chloride) salt data are correlated. At greater depth, continual wetting with salt and subsequent heating increases permeability and pore connectivity of the sandstone block. Salt crystallization enlarges and fractures pores, enabling the ingress and movement of soluble chloride salts. The stone’s intrinsic properties (permeability and porosity) have been changed by salt weathering, ultimately leading to deterioration and accelerated stone decay.